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Psilocybin is a hallucinogen that people can ingest through certain types of mushrooms.
How it works
Psilocybin works by activating serotonin receptors, most often in the prefrontal cortex. This part of the brain affects mood, cognition, and perception. Hallucinogens also work in other regions of the brain that regulate arousal and panic responses.
Psilocybin does not always cause active visual or auditory hallucinations. Instead, it distorts how some people that use the drug perceive objects and people already in their environment.
The quantity of the drug a person consumes, their past experiences, and their expectations of how the experience will take shape can all impact the effects of psilocybin.
The hallucinogenic effects of psilocybin usually occur within 30 minutes after a person ingests it and last 4–6 hours. In some individuals, changes in sensory perception and thought patterns can last for several days.
The potency of a magic mushroom depends on:
- growing conditions
- harvest period
- whether a person eats them fresh or dried
The amount of psilocybin in dried mushrooms is about 10 times higher than that found in their fresh counterparts.
Psilocybin mushrooms (also known as magic mushrooms, psychedelic mushrooms, and shrooms) are a family of psychoactive mushrooms that contain psilocybin, a psychedelic substance of the tryptamine class. Psilocybin mushrooms occur on all continents and have been taxonomically classified into over 200 species, the most potent of which belong to the genus Psilocybe. Psilocybin mushrooms produce their effects by acting on serotonin receptors in the brain; however, the precise mechanism is not known.
Psilocybin mushrooms are thought to have been used by various human cultures since before recorded history, based on imagery found on prehistoric rock art. In Mesoamerica, they have been consumed in ritual ceremonies for 3000 years. Following its introduction to American society in 1955 by Gordon R. Wasson, psilocybin was subject to experimental research of mental disorders and in psychotherapy throughout the 1960s. Magic Mushroom UK
Popularization by 1960s counterculture figures like Timothy Leary led to an explosion of recreational use and resulted in its prohibition in 1970. Today, psilocybin mushrooms are one of the most widely used psychedelics and the subject of renewed interest by researchers and clinicians in the treatment of depression and other disorders.
Subjective effects include open and closed-eye visuals, time distortion, enhanced introspection, conceptual thinking, euphoria, and ego loss. Notably, the intensity and duration of effects produced by psilocybin mushrooms can vary greatly depending on factors such as species and batch, which can complicate standardized dosing information (see this section).
Psilocybin mushrooms are commonly described by users to evoke entheogenic and mystical-type or transpersonal experiences that can facilitate introspection and personal growth. Unlike most highly prohibited substances, psilocybin mushrooms have been shown to be neither addictive nor physiologically toxic.
See the Clinical Research Page for published papers on clinical trial results with some amazing results , which confirm what many ancient cultures around the world have known for thousands of years , that these plants ARE MEDICINES! Provided by nature , and as we are part of nature it makes complete sense that these plant medicines work miracles!
There is evidence that suggests that psychoactive mushrooms have been used by humans in religious ceremonies for thousands of years. Murals dated 9000 to 7000 BCE found in the Sahara desert in southeast Algeria depict horned beings dressed as dancers holding mushroom-like objects. 6,000-year-old pictographs discovered near the Spanish town of Villar del Humo illustrate several mushrooms that have been tentatively identified as Psilocybe hispanica, a hallucinogenic species native to the area.
Archaeological artifacts from Mexico have also been interpreted by some scholars as evidence for ritual and ceremonial usage of psychoactive mushrooms in the Mayan and Aztec cultures of Mesoamerica. In Nahuatl, the language of the Aztecs, the mushrooms were called teonanácatl, or “God’s flesh”. Following the arrival of Spanish explorers to the New World in the 16th century, chroniclers reported the use of mushrooms by the natives for ceremonial and religious purposes. Accounts describe mushrooms being eaten in festivities for the accession of emperors and the celebration of successful business trips by merchants.
After the defeat of the Aztecs, the Spanish forbade traditional religious practices and rituals that they considered “pagan idolatry”, including ceremonial mushroom use. For the next four centuries, the Indians of Mesoamerica hid their use of entheogens from the Spanish authorities.
American banker and amateur ethnomycologist R. Gordon Wasson studied the ritual use of psychoactive mushrooms by the native population of a Mazatec village in Mexico. In 1957, Wasson described the psychedelic visions that he experienced during these rituals in “Seeking the Magic Mushroom”, an article published in the popular American weekly Life magazine.
3,4-Methylenedioxymethamphetamine (also known as ecstasy, E, XTC, emma, molly, mandy, and MDMA) is a classical entactogen substance of the amphetamine class. MDMA is considered to be the parent compound of the entactogens, a diverse group that includes MDA, methylone, mephedrone, and 6-APB. It produces its psychoactive effects by promoting the release of neurotransmitters serotonin, dopamine, and norepinephrine in the brain.
MDMA was first developed in 1912 by the pharmaceutical company Merck. However, there is no documentation of human use prior to the 1970s, when it became known in underground psychotherapy circles in the United States. In the early 1980s, MDMA spread into nightlife and rave culture, eventually leading to its federal scheduling in 1985. By 2014, MDMA was estimated to be one of the most popular recreational drugs in the world, alongside cocaine and cannabis. Recreational MDMA use is popularly associated with dance parties, electronic dance music, and the club and rave scene. Researchers are currently investigating whether MDMA may assist in treatment-resistant post-traumatic stress disorder (PTSD), social anxiety in autistic adults, and anxiety in those with life-threatening illness.
Subjective effects include stimulation, anxiety suppression, disinhibition, enhanced empathy and sociability, relaxation, and euphoria. MDMA is classified as an entactogen due to how it facilitates feelings of closeness with one’s self and others. Tolerance to MDMA builds unusually quickly and many users report that it dramatically loses its effectiveness if used on a frequent basis. It is commonly recommended to wait one to three months between each use to give the brain adequate time to restore serotonin levels and avoid toxicity. Additionally, using excessively high doses and multiple redosing is highly discouraged as these are thought to significantly increase toxicity.
MDMA has been shown to be extremely effective again PTSD/CPTSD , people who we have treated MDMA for PTSD have reported that it is nothing short of a miracle. Years of suffering have ended sometimes after just one session! Please read the Papers published in our Clinical Research Section.
MDMA was first synthesized in 1912 by the German chemist Dr. Anton Köllisch while employed at the pharmaceutical company Merck. Köllisch was in the process of developing agents that would help manage excess bleeding and was interested in MDMA synthesis because it was an intermediate in the production of methylhydrastinin, the methylated analogue of the hemostatic agent hydrastinine. There are no indications of interest in MDMA as an active agent itself. MDMA was not mentioned again until 1927, when Dr. Max Oberlin conducted the first proven pharmalogical tests at Merck while searching for compounds with a similar action spectrum to adrenaline or ephetonine. Despite promising results, research was halted due to rising substance prices.
In 1965, the American chemist Alexander Shulgin synthesized MDMA as an academic exercise but did not test it for psychoactivity. Shulgin claims to have first heard about the effects of MDMA in 1967 from a student and decided to experiment with it himself. He was impressed with the effects of the substance and believed it could have therapeutic utility. He advertised it to therapists and psychiatrists which led it to gain some popularity as an adjunct treatment for various psychological disorders. During this period, psychotherapist Dr. Leo Zeff came out of retirement and subsequently introduced the then-legal MDMA to over 4,000 patients. From the mid-1970s to the mid-1980s there was a growth of clinicians using MDMA (then known as “Adam”) in California.
From the mid-1970s to the mid-1980s there was a growth of clinicians using MDMA (then known as “Adam”) in California.
Recreational use of MDMA became popular at around the same time, particularly in nightclubs, eventually catching the attention of the Drug Enforcement Administration (DEA). After several hearings, a US Federal Administrative Law Judge recommended that MDMA should be made a Schedule III controlled substance so that it could be used in the medical field. Despite this, the director of the DEA overruled this recommendation and classified MDMA as a Schedule I controlled substance.
In the United Kingdom, the 1971 Misuse of Drugs Act, which had already been altered in 1977 to include all ring-substituted amphetamines like MDMA, was further amended in 1985 to refer specifically to Ecstasy, placing it in the Class A category.
N,N-Dimethyltryptamine (also known as DMT, N,N-DMT, Dmitri, and “The Spirit Molecule”) is a classical psychedelic substance of the tryptamine class. Despite being one of the simplest psychedelic compounds, it is known for its unique ability to produce short-lived but intense visionary states and complete hallucinations. It is thought to produce its psychedelic effects by binding to serotonin receptors in the brain, although the precise mechanism is not fully understood.
DMT is present in over 65 species of plants and has been identified as being a normal constituent of human metabolism and an endogenous neurotransmitter in certain rodents. Its presence is also known to be widespread throughout the plant kingdom. Although various theories have been postulated, its neurobiological function has yet to be determined.
Depending on the dosage and method of administration, the effects of DMT can range from mild psychedelic states to powerfully immersive life-altering experiences which are often described as the ultimate displacement from ordinary consciousness in which users report experiencing ineffable spiritual realms or alternate dimensions.
When vaporized or smoked, DMT produces short-lived effects with a very rapid onset that is sometimes described as an “inconceivably high-speed rollercoaster ride.” When ingested in combination with a MAOI or RIMA agent, it becomes active orally and significantly longer lasting, immersive, and interactive in nature: this combination is known as ayahuasca. Ayahuasca brews have been used traditionally in South America since at least around the year 1500.
DMT has been used successfully to treat years of addiction , trauma , depression and anxiety.
Very profound and life changing experience!
History and culture of DMT
DMT was first synthesized in 1931 by the German chemist Richard Helmuth Fredrick Manske. Its discovery as a natural product is generally credited to Brazilian chemist and microbiologist Oswaldo Gonçalves de Lima who, in 1946, isolated an alkaloid he named nigerina (nigerine) from the root bark of jurema preta (Mimosa tenuiflora).
It was unequivocally identified in 1959, when American chemists were provided a sample of Mimosa tenuiflora.In 1955, a team of American chemists led by Evan Horning isolated and formally identified DMT in the seeds and pods of Anadenanthera peregrina.
Since 1955, It has been found in a host of organisms: in at least fifty plant species belonging to ten families, and in at least four animal species, including one gorgonian and three mammalian species.
5-Methoxy-N,N-dimethyltryptamine (also known as 5-MeO-DMT) is a naturally-occurring psychedelic substance of the tryptamine class. It is distributed in a wide variety of plant species, as well as in the venom of a single psychoactive toad species (Bufo Alvaris). It is structurally related to DMT and 5-HO-DMT (bufotenine) and produces some of the most powerful, intense, and short-lived psychedelic experiences known to man. 5-MeO-DMT produces its effects by binding to serotonin receptors in the brain, although the precise mechanism is not known.
5-MeO-DMT has been used as an entheogen by South American shamans for thousands of years. In modern times, both the extracts of the toad venom as well as synthetic powder form are used, primarily via vaporization. Its synthesis and psychoactive effects were documented in Alexander Shulgin’s 1997 book TiHKAL (“Tryptamines I Have Known and Loved”). Recent studies have demonstrated its capacity to induce mystical experiences and there is interest in its potential therapeutic effects.
Subjective effects include unity and interconnectedness, time distortion, conceptual thinking, euphoria, and ego loss. 5-MeO-DMT’s psychedelic effects are best compared to DMT in intensity (extreme) and duration (very short). However, it differs in that it generally lacks a visual component, is significantly more tactile and euphoric, and produces even stronger transpersonal effects like unity and interconnectedness and ego loss. Additionally, both mental and physical side effects are more often reported with 5-MeO-DMT, which is sometimes described as overwhelming and capable of producing panic attacks, dysphoria, as well as significant nausea and bodily discomfort.
5-MeO-DMT is also known as “The God Molecule” and many users report this medicines lets you experience “The Source” or God , Creator etc. as it will let you have the complete “Oneness” experience this is one of pure and utter love!
This medicine is considered the most powerful Psychedelic currently known to man!
Magic mushrooms, or “shrooms,” are a type of mushroom containing psilocybin, a hallucinogenic compound. The length of time shrooms stay in a person’s system depends on many factors, including the strength of the mushroom, dose, and the individual’s body.
People may take shrooms for spiritual or recreational purposes. Its hallucinogenic compounds can induce intense and long-lasting effects.
These effects could last for hours, with no set time on when they will end. Similar factors may also play a role in how long shrooms take to kick in and whether they show up on a drug test.
Keep reading to learn more.
A person’s kidneys process the compounds in magic mushrooms, which include psilocybin, the primary ingredient responsible for shrooms’ hallucinogenic effects.
The process happens relatively quickly, and in many cases, the kidneys excrete most of them from a person’s system in a few hours.
Researchers note that about 66% of the compounds from shrooms get excreted in the first 3 hours after ingestion. After 24 hours, psilocybin becomes undetectable in a person’s urine.
However, there is no exact time on how long other compounds will stay in the system, or how long the shrooms’ effects will last.
Several factors may play a role in how the body handles these compounds, such as a person’s weight and metabolism, as well as the dose and type of mushroom ingested.
When shrooms are in a person’s system, how long they can remain detectable in drug tests can also vary widely.
There are various drug tests available, with their own factors in screening methods, detection, and accuracy.
The Drug & Alcohol Testing Industry Association list common drug tests and the compounds they detect. The most common screening is the five-panel test, which tests for the following substances:
- opiates, such as heroin
- phencyclidine, or PCP
In addition, there are eight- and 10-panel tests.
None of these screenings, including the five-panel test, check for the compounds contained in shrooms.
However, other tests can detect hallucinogenic compounds, although the screenings may need administering promptly. This is because the body metabolizes the shrooms and their compounds relatively quickly. After 24 hours, a urine, blood, or saliva test may not detect mushrooms in a person’s system.
Despite this, other screenings, such as a hair follicle test, may detect drugs over a longer period after ingestion, although they might not identify these substances in the first few days after exposure.
Shrooms can stay active in a person’s body for hours. Research suggests that the hallucinogenic effects may last 3–6 hoursTrusted Source after ingestion.
While the exact timings vary from person to person, other factors may also play a role. These include:
- weight and body composition
- type of shroom and amount a person consumes
- preparation of the mushrooms, for example, dried or in tea
- tolerance levels
- the state of mind of the person taking them
- preexisting mental health conditions
- other drugs or substances a person takes at the time
In addition, some people may be more sensitive to these compounds and experience a longer “high” or lingering effects after the initial high passes.
Following ingestion, magic mushrooms take some time to start affecting the body. Research notes that hallucinogenic effects may commence within 20–40 minutes.Trusted Source
While there are some natural variations to this, many people feel the effects of taking shrooms within 1 hour.
These effects may come on gradually. A person may feel minor changes in their senses or feelings initially, which then progress to stronger visual, auditory, or other sensory hallucinations.
The immediate effectsTrusted Source of hallucinogenic mushrooms come from the body breaking down psilocybin into psilocin. Psilocin acts in the brain similarly to other hallucinogens such as lysergic acid diethylamide, commonly known as LSD.
After ingesting shrooms, a person may feel relaxed or drowsy, while others may experience a sense of unity or peace with their surroundings. These sensations may progress and get more intense.
The immediate effects generally only last a few hours. Some may experience a lingering sense of ease from a positive experience or a lingering sense of unease from a negative one.
In addition, a higher dose can trigger feelings of euphoria and hallucinations. These can be visual and auditory, while a person can also have extrasensory experiences within the body and mind.
These hallucinatory effects can be positive or negative, perhaps due to a person’s frame of mind and surroundings. A negative experience may cause people to feel paranoid, anxious, or panicked. In contrast, a positive experience may cause a person to feel intense euphoria or awe.
People should note that there are some risks when ingesting magic mushrooms.
A person can have an unenjoyable experience, or “bad tripTrusted Source,” while taking shrooms. These bad trips may cause:
- feelings of intense confusion and fear
- bad or scary hallucinations
- difficult changes in their psychological state
A more intense trip may disconnect a person from reality or make it difficult for them to understand what is real and what is a hallucination.
The experience and sensations may have associations with a person’s current mental state and surroundings.
There may also be some physical side effects from taking the mushrooms, including:
- stomach ache
- muscle weakness
- lack of coordination
The Drug Enforcement Administration (DEA) note that using shrooms could lead to poisoning if a person takes a misidentified mushroom. Some poisonous mushrooms may appear similar to hallucinogenic shrooms, and taking them could lead to serious or potentially fatal issues.
The DEA also state that it is possible to overdose on shrooms, which may cause:
- a longer, intense trip
- psychotic episodes
There is also the risk of criminal prosecution for using the substance. The federal government consider psilocybin a Schedule 1 substance, similar to drugs such as heroin and crack cocaine. This means the compound is considered highly abusable, has no medical use, and lacks accepted safety measures for use under supervision.
The medical community has some interest in potential medicinal uses for hallucinogenic mushrooms.
Some research suggests that psilocybin from shrooms could help treat several health issues, such as:
- alcohol use disorder
- tobacco dependence
- obsessive-compulsive disorder
- treatment-resistant depression
However, it is important to note that research is in the early stages. More studies are needed to determine if magic mushrooms can definitively serve as an effective form of treatment.
Anyone who suspects they are experiencing poisoning from a magic mushroom should seek immediate medical attention.
A person suffering from a bad trip does not necessarily need to go to the hospital. However, intense feelings or a total detachment from reality may indicate an intense trip or overdose. Monitoring the person or taking them to the hospital may be the best course of action in these cases.
People who feel they are becoming psychologically dependant on magic mushrooms could benefit from seeing a mental health expert.
Constantly chasing altered state experiences using hallucinogens may indicate a risk for psychological dependency.
Hallucinogenic mushrooms contain compounds that act on the brain to cause their effects. Taking these shrooms can cause hallucinatory sensory experiences that may last hours.
The body metabolizes the compounds in magic mushrooms relatively quickly, while the shrooms and their compounds may be out of the body within 24 hours in most cases.
Common drug tests involving saliva or blood samples will not likely screen for the hallucinogenic compounds in shrooms. Specific tests to identify them will need administering within around 24 hours after ingestion to detect these substances.
There are some risks to consider before using mushrooms, and some people may wish to avoid them altogether.
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